Objective: To study the expression of hyaluronic acid synthase 2 in renal cell carcinoma and to investigate its potential clinical significance. Methods: using three subtypes of real-time quantitative polymerase chain reaction (qPCR) method for the detection of five kinds of renal cell carcinoma (ACHN and Caki-1, os-rc-2 and 786-o, SN12PM6) of hyaluronic acid synthase (HAS1, Has2, has3) mRNA expression and further to detect the mRNA expression of high content of HSA subtypes in five renal cell carcinoma cell line and clear cell renal cell carcinoma (ccrcc) tissue protein expression by Western blot method. Results: in the five kinds of renal cell carcinoma cell line HAS2mRNA expression levels were significantly higher than that in normal renal tubular epithelial cells (HK-2), which in renal cell carcinoma SN12PM6 cell lines in the expression level was the highest (P% 26lt; 0.05). HAS1mRNA expression levels were significantly lower than normal renal tubular epithelial cells (all P% 26gt; 0.05), and HAS3mRNA expression level except for renal cell carcinoma Caki-1 cell lines were lower than those of normal renal tubular epithelial timberland Canada Stores cells (P% 26gt; 0.05). HAS2 timberland Canada Online protein expression was significantly expressed in five kinds of renal cell carcinoma cell lines, but no expression of normal renal tubular epithelial cells. The expression of HAS2 protein in renal clear cell carcinoma tissues was significantly higher than that of the corresponding para carcinoma tissues. Conclusion: hyaluronan synthase 2 in a variety of renal cell carcinoma cell line and renal clear cell carcinoma were expressed, suggesting that hyaluronan synthase 2 in renal cell carcinoma, especially in renal timberland Boots Canada clear timberland Canada Customer Service cell carcinoma occurring in the process of development plays a crucial Timberland Canada role in some and may become a new renal clear cell cancer molecular markers.